Ganosa is a colloquial and somewhat provocative term derived from ganas, meaning 'desire' or 'urge'. While ganas is common, ganosa specifically implies a strong, often sexual, desire or eagerness.
In this song, Maluma uses it directly in the opening line, "Baby, cuando estés ganosa, call me" (Baby, when you're horny/eager, call me). This sets a clear tone for the song's theme of intense desire and intimacy, making it a memorable and central word for understanding the lyrics.
Maluma spends this whole song waiting by the phone. The hook is a standing offer with a Spanglish punchline: "Baby, cuando estés ganosa, call me" (Baby, when you're in the mood, call me), and ganosa is the Colombian word doing all the work, sitting somewhere between wanting and not being shy about it. Everything after that is logistics. "Llámame, yo paso por ti" (Call me, I'll pick you up). "Caiga, reina, pa' Medellín" (Come on over, queen, to Medellín).
The bragging lands because it is so specific. He offers to cover her subscription page in "Yo te pago el Only" (I'll pay for your Only), promises paperwork before romance with "Cántemela y yo le saco visa" (Just say the word and I'll get you a visa), then upgrades the trip: "Y en el jet pri nos vamos pa' Ibiza" (And on the private jet we're off to Ibiza). The one line that sounds like an actual observation rather than an offer is "Ella es tímida, pero con instinto animal" (She's shy, but with an animal instinct). By the second verse he has dropped the romance framing entirely and moved her onto the books: "Tú eres única, entras en la nómina, mami" (You're unique, you're on the payroll, babe). Whether that counts as a compliment is between them.