Agüitarse is a colloquial verb, particularly common in Mexican Spanish, that means 'to get sad,' 'to get discouraged,' or 'to feel down.' It's a more expressive and less formal way of saying 'entristecerse' or 'desanimarse'.
In "LA DURANGO," Peso Pluma uses this word multiple times to emphasize resilience and a winning mindset. He sings, "Aquí el que se agüita pierde, así que nunca se me agüite" (Here, whoever gets discouraged loses, so never get discouraged). It's a key theme in the song, encouraging listeners to stay strong and not let setbacks get to them.
Peso Pluma, Junior H, and Eslabon Armado are here to celebrate making it big. The whole song is a victory lap, centered on the image of a Dodge Durango with blacked-out windows. It's a symbol of success earned through hard work. Peso Pluma makes it clear he didn't get lucky: "No se me asusten, con esfuerzo me lo gané" (Don't be scared, I earned it with effort). He's enjoying the results, riding around with beautiful women—"Morritas montadas en la Durango y van bien cake" (Girls riding in the Durango and they look really good)—and keeping nosy people out of his business.
This isn't just a party song, though. It's also a message to his crew and his rivals. He values loyalty above all, stating his friends are still with him: "Mis compas siguen aquí, a mi lado / Las cosas aquí no han cambiado" (My buddies are still here, by my side / Things here haven't changed). And for anyone trying to copy his style, he has a blunt message: "Pinches copiones, ya agárrense su propio flow" (Fucking copycats, get your own flow). The song is a confident statement about enjoying life, staying true to your friends, and reaping the rewards of your own hard work.