Agüites is a very common slang term in Mexican Spanish. It comes from the verb agüitarse, which means 'to get sad', 'to get down', or 'to be bummed out'.
In the song, the singer says, "Mija, no te agüite'" which translates to "Girl, don't be sad." It's the kind of informal, friendly word you'd use with friends, making it a fantastic piece of slang to add to your vocabulary!
This song is all about a relationship with absolutely no strings attached. Fuerza Regida and Anuel AA are very clear from the start: they like the girl, but love is not part of the deal. They lay it all out with lines like, "Nunca podrá' decir que yo te amé" (You can never say that I loved you) and "Tú me encantas, pero no voy a enamorarme" (I'm enchanted by you, but I'm not going to fall in love). It’s a blunt agreement between two people who just want to have fun without any emotional complications.
The whole vibe is built on this idea of being wild and free. They call themselves "coco loco" (crazy coco) and her "loquita" (a little crazy), suggesting they're a perfect match for this kind of arrangement. The lyrics are full of references to a dangerous, narco lifestyle, comparing their bond to infamous figures like Pablo Escobar and El Chapo. It's an intense way of saying their connection is thrilling and secretive, but definitely not a traditional romance. They repeat the main rule of their game over and over: "tú no te enamora', esto no es nada serio" (you don't fall in love, this is nothing serious).