Brujería literally translates to "witchcraft" or "sorcery". It's a fantastic word that adds a layer of magic and mystery to the song.
Here, the singer feels so powerless against a woman's charm that he wonders if he's the victim of a magic spell. He asks, "¿qué se hace cuando te hacen brujería?" (what does one do when witchcraft is performed on you?), perfectly capturing the feeling of being irresistibly and inexplicably drawn to someone dangerous.
This song is a warning about a specific type of woman: the femme fatale. Victor Manuelle and Bad Bunny describe a woman who is so beautiful and confident that she's dangerous. They call her "mala, mala, mala, mala y peligrosa" [bad, bad, bad, bad and dangerous] right from the start. She's got the whole package: "Ojos café, un cuerpo bien / Olor espectacular" [brown eyes, a great body / spectacular scent], and she knows it. The song says she's a "mujer que vive segura de sí misma, es toda una diosa" [a woman who is sure of herself, she's a total goddess].
But this goddess has a dark side. Bad Bunny calls her a "diabla con cara de diosa" [a devil with the face of a goddess] who is as risky as "ruleta rusa" [Russian roulette]. He says she uses men after enchanting them with her dancing. The singers know they're playing with fire and that getting involved will probably "terminar mal" [end badly]. They know her kisses are full of "veneno y de malicia" [venom and malice], but they can't resist. She's an addiction they can't seem to shake, even when they know better.