Desacatado literally means 'disobedient' or 'contemptuous'. In the high-energy context of "Pepas", it's slang for being completely wild, uninhibited, and letting loose on the dance floor.
Farruko uses this powerful adjective to paint a picture of the entire club losing control and giving in to the music's energy. It perfectly captures the song's core theme of a carefree, explosive party where all rules are off.
Farruko's "Pepas" is a massive party anthem with a very simple and direct message: live your life and don't worry about what anyone else thinks. He kicks it off by saying, "No me importa lo que de mí se diga / Viva usted su vida, que yo vivo la mía" (I don't care what they say about me / You live your life, and I'll live mine). This isn't a song with hidden meanings. It's about seizing the moment because, as he puts it, "el tiempo se acaba y pa'trás no vira" (time is running out and it doesn't turn back).
This song describes an all-night party that gets completely wild. The chorus is a blunt description of the scene: "Pepa y agua pa' la seca / To' el mundo en pastilla en la discoteca" (A pill and water for the dry mouth / Everyone's on pills at the nightclub). The party doesn't even stop when the sun comes up. Instead, Farruko says the sun is out, so it's time to "prende la hookah y el alcohol" (light the hookah and the alcohol) because "esto se salió de control" (this got out of control). It's a pure celebration of hedonism and losing yourself to the music until morning.