Desenfocao' is the Caribbean Spanish colloquial shortening of desenfocado, which literally means "out of focus," like a blurry photo.
Rauw Alejandro uses it to describe feeling dazed and directionless after partying hard. The word is vivid, uncommon in everyday speech, and instantly paints a picture of a mind that can't quite sharpen its view—perfect for grabbing a learner’s attention.
Rauw Alejandro is having a wild night out, but something's not right. The title says it all: he's "Desenfocao'" [Unfocused]. He's partying so hard he can't feel his face, he's been up all night—"Que salió el sol, no sabía" [I didn't know the sun had come up]—and he's so out of it he calls a girl by the wrong name: "Le dije María y se llama Sofía" [I called her María and her name is Sofía]. The whole song feels like a dizzying blur of fast cars, expensive clothes, and drugs.
But this isn't just a party song. All this chaos is a distraction from a painful breakup. He admits he doesn't want to be this way, but it feels good "Porque ya no estás" [Because you're not here anymore]. He's trying to escape a memory that even the partying can't erase. It's a lonely feeling, summed up perfectly in the line "La cama llena y yo vacío, desierto" [The bed is full but I'm empty, a desert]. He's surrounded by people but feels completely lost without the one person he's trying to forget.