Aniquilado literally means "annihilated" or "destroyed". It's a very strong and dramatic word that you don't typically find in a romantic song.
Juanes uses this powerful verb to express the utter devastation he feels when his loved one isn't there: "Me siento aniquilado si no estás" (I feel annihilated if you're not here). This intense exaggeration paints a vivid picture of emotional collapse, making it an impactful word that captures the song's passion.
This song is a huge, open-hearted declaration of love. Juanes isn't being subtle here; he's telling someone they are the absolute center of his universe. He wakes up and if they're there, he feels "renovado" [renewed], but if they're not, he feels "aniquilado" [annihilated]. That's a pretty intense way to start your day!
The whole song is built on this contrast. With this person, his eyes shine, his heart beats, and he's even started to talk about love again. Without them, he's a "vagabundo / Perdido por el mundo" [a vagabond / lost in the world]. Every good thing, from his heartbeat to his peace of mind, is because of them. It's a classic power ballad from the Colombian star, full of beautiful images like skin the color of a "rojo atardecer" [red sunset] and eyes that lead him to the sun.