"Maníaca" is Abraham Mateo spelling out his obsession letter by letter: the song literally opens and closes with "M-A-N-Í-A-C-A", like a cheerleader chant for the girl who owns the dance floor. She shows up "descontrolada" (out of control), "quemó la sala" (she set the room on fire), and he is hooked from the first look. By the chorus she is "adicta al dembow, también reggaetón" (addicted to dembow, and reggaeton too). Dembow is the Dominican-born drum pattern that sits under almost every reggaeton hit, so she is basically addicted to the beat itself.
The verse is the fun part, because it paints a full character in a few quick lines. "Por el día va a la uni y por la noche a la disco" (by day she goes to uni and by night to the club): "uni" is the casual word for "universidad". She only goes out "con la pulsera V.I.P" (with the VIP wristband), "to' la miran" (everyone looks at her, with "to'" short for "todos"), and she "suda cada gota de alcohol del San Francisco" (sweats out every drop of alcohol in the San Francisco), a joke, since a San Francisco is a fruity cocktail that usually has no alcohol. He calls each of her steps "mi dosis de dopamina" (my dose of dopamine), says she has "fama de asesina" (a reputation as a killer) on the dance floor, and that her favourite film is Flashdance, the 1983 movie about a dancer. It is silly, catchy and completely over the top, which is exactly the point.