Calzón literally translates to "underwear" or "panties." It's a very informal and somewhat provocative word that immediately grabs attention because it's not commonly featured in song titles or prominent lyrics in a straightforward way.
In the song, the phrase "Mezcal de calzón" is a playful and suggestive twist on the idea of being so infatuated that it feels like a potent, intoxicating drink (mezcal) that has gone straight to your head, or perhaps even deeper, implying a strong, almost primal attraction. It's a memorable and intriguing choice that hints at the song's flirtatious and passionate tone.
Have you ever been so smitten you just can't sleep or even enjoy your usual fun? That's exactly where Eden Muñoz is in "Mezcal De Calzón." He's so consumed by someone new that his friends are asking, "¿Qué onda? ¿Qué pedo? ¿Qué pasa? Que de una ya no quieres pistear con la raza?" [What's up? What's the deal? What's happening? You don't want to drink with the crew anymore?]. He jokes that it must be "Mezcal de calzón" [Mezcal of underwear] because he can't find any other reason for being so crazy about her photos and her body.
He's not just a little interested; he's all in! Eden wants to be everything to this person: her driver, so he can "manejarte a mi antojo" [drive you as I please], and even get jealous if anyone else looks at her. He wants to be "El primero que pienses cuando te levantes" [The first one you think of when you wake up] and "Quien te quite las ganas cuando ya no aguantes" [The one who takes away your desires when you can't take it anymore]. He even says he'll give up partying and chaos for her "cara angelical" [angelic face]. It's a fun, over-the-top declaration of infatuation!