Desconfigurar literally means "to deconfigure" or "to mess up the settings," like you would on a computer. It's a technical term given a brilliant new life in this song.
Boza sings, "si me besas, me desconfiguro" (if you kiss me, I get all messed up), using the word to describe how a kiss completely short-circuits his brain and throws him off balance. It's a fun, modern, and memorable way to express being overwhelmed by attraction.
This song is a back-and-forth between two people who are falling for each other but are both a little hesitant because of past hurts. It's a classic "I like you, you like me, but let's be careful" story, set to a super smooth reggaeton beat.
Boza starts off completely smitten. He feels like he's floating on a cloud—"Tú me tienes en una nube / Todavía no he aterrizado" (You have me on a cloud / I still haven't landed)—and says her kiss totally reconfigures him. He promises to heal her past pain, saying, "Si te dañaron, yo te cu-cu-curo" (If they hurt you, I'll cure-cure-cure you). He even gets a bit cosmic, offering to make love on "el cinturón de Orión" (Orion's belt), which is where the song gets its title. Then ELENA ROSE comes in with her side of the story. She admits, "De tenerte, también tengo ganas" (I also feel like having you), but she needs to take it slow. She explains that she's been hurt before and doesn't want to mess things up with her own issues. She has one of the best lines in the song to describe her emotional state: "Mi corazón está como Miami / Siempre bajo construcción" (My heart is like Miami / Always under construction). It's a perfect way to say she's a work in progress, and her only rule is putting herself first.