"20 Labios" is a breakup song that pretends to be a party song. The singer has spent "mil noches encerrado aquí" (a thousand nights locked in here) while his ex walks around looking happy, and he cried "como un tsunami" (like a tsunami). He thought about writing her letters but turned them into origami instead, which is a funny, sad little image.
So he calls "to' mis panas" (all my buddies; to' is short for todos and panas is slang for friends), orders an aguardiente (a strong liquor) and heads out to forget her. The chorus is the whole joke and the whole wound: "Ya me tomé diez copas, bailé con quince locas, he probado veinte labios, pero extraño tu boca" (I've had ten drinks, danced with fifteen crazy girls, tried twenty lips, but I miss your mouth). He even admits "reír pa' no llorar" (laughing so I don't cry). Lost in Buenos Aires, broke and kissing strangers, he still asks "¿a quién quiero engañar?" (who am I trying to fool?).