Virar literally means "to turn". However, in Puerto Rican slang, it takes on a completely different meaning: to betray someone or turn on them.
In "Pinot Grigio", Young Miko celebrates her success and loyalty. When she says, "La gente cambia, pero ellos no se me viran" (People change, but they don't turn on me), she's using this powerful slang to emphasize that her true friends will never betray her, no matter how famous she gets.
This song is a toast to success, loyalty, and living the good life. Young Miko is celebrating making it big with the same crew she started with. She raises a glass—specifically, a bottle of Pinot Grigio—to them, shouting out that even though people change, her friends never will: "La gente cambia, pero ellos no se me viran" (People change, but they don't turn on me). She's not interested in new friends ("Amigos nuevos, no, paso" [New friends, no, I'll pass]) because she has everything she needs with her loyal circle who have her back.
Throughout the track, Miko flexes the rewards of her hard work. She's got full pockets and sold-out venues ("Lleno' los bolsillo', también lleno' los venue" [Pockets full, also the venues are full]). She's rocking expensive jewelry and exclusive brands, enjoying views of the ocean, and moving from a Can-Am to a Sea-Doo with her crew. It's a confident anthem about enjoying success with the people who were there from the beginning, completely unbothered by anyone who wishes them ill.