Desespero comes from the verb 'desesperar', which means 'to despair' or 'to lose hope'. In the song, it's used as a reflexive verb in the powerful line: "Si estos ojos no te miran, yo me desespero" (If these eyes don't see you, I get desperate).
This is a highly emotional word that perfectly captures the song's dramatic and passionate tone. The singer uses it to express a feeling beyond simple sadness, a state of anguished desperation without his love. It's a great example of the raw, heartfelt emotion that defines Regional Mexican music.
This song is about being so completely in love that the other person becomes your entire world. The singer isn't just fond of his partner; he feels a physical need for her. He says, "Si estos ojos no te miran / Yo me desespero" [If these eyes don't see you / I get desperate] and even more intensely, "Si mis manos no te tocan / Siento que me muero" [If my hands don't touch you / I feel like I'm dying]. It's a powerful declaration that nothing else matters.
The chorus makes it crystal clear: "Tú, solamente tú / No necesito de nadie" [You, only you / I don't need anyone else]. He wants his partner to see herself the way he does, telling her to look at her face in a "espejo lleno de diamantes" [mirror full of diamonds]. Ultimately, his one request is that she loves him back with the same intensity he feels for her in every single moment.