Opacaba comes from the verb opacar, which means to overshadow, dim, or make something less bright or prominent. It's a vivid, visual verb rarely heard in everyday conversation.
In the song, the lyrics describe how one person's presence overshadowed someone else, singing "To' se lo opacaba" ("She overshadowed him"), using the word to show just how completely she outshined everyone and everything around her.
"FKU" follows a woman shaking off a bad relationship and turning the breakup into her comeback. She used to get dressed up for a guy who slowly dimmed her light — "Pero le tocó un loco / Que poco a poco / To' se lo opacaba" ("But she got stuck with a crazy one / who little by little / dimmed it all") — and when he won't let her go, she settles it with one line that covers both sides: "Lo insultó y le dijo fuck you... También le dijo thank you" ("She cursed him out and said fuck you... she also told him thank you") — fuck you for the damage, thank you for the lesson. From there she's back out until sunrise, waterproof makeup on in case the night gets sweaty — "Hoy se maquilló de más / Y se lo puso waterproof / Por si baila de más" ("Today she put on extra makeup / and made it waterproof / in case she dances too much") — done being anyone's plan B. Dímelo Flow, Divino and iZaak trade the verses over a perreo beat, signing off with their own names as the closing tag.