Manipularme means "to manipulate me." It's an interesting and somewhat intense word to find in a pop song, suggesting a deeper emotional conflict beyond simple heartbreak.
In the context of the song, the singer realizes his ex-partner is not being genuine when she talks about returning. He sings, "Que tú me mientes y quieres manipularme" (That you lie to me and want to manipulate me), highlighting his awareness of her deceptive intentions and his refusal to be controlled.
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