Desorientao' is the song's colloquial pronunciation of desorientado, meaning “disoriented” or “lost.” The dropped -d- reflects the pronunciation common in Caribbean Spanish, making this a useful and memorable example of how spoken Spanish can differ from its formal spelling.
In the song, the singer feels emotionally lost after waking up without the person he loves, capturing his confusion and heartbreak.
A man wakes up and the first thing in his head is that she's gone for good: "Acariciando la noticia de que tú no volverás" [Mulling over the news that you won't come back]. Nothing around him has changed, and that's the problem. "Y hoy desperté en la misma casa, en el mismo cuarto" [And today I woke up in the same house, in the same room], in the same bed where they were together, and every familiar thing just reminds him she isn't in it.
The second verse drops any pretence of being tough with "Entiéndame, los hombres también lloran" [Understand me, men cry too], a blunt line for a 2006 reggaeton hit. The chorus is a list of what he's missing, "Si no tengo de tu piel" [If I can't feel your skin], and it keeps landing on the English word "down", switching to English for "Girl, I'm dying for your love" as if Spanish ran out. It's a sad song you can dance to, which is exactly why it stuck.