Desconfigura is a creative and modern verb you won't find in your textbook. It literally means "to deconfigure," like messing up the settings on a computer or phone.
In "LA FALDA," Myke Towers uses this tech term metaphorically. When he says, "Ella a mí me desconfigura", he means she completely messes with his head and throws him off balance, as if his brain has short-circuited just by seeing her. It’s a perfect example of modern slang mixing technology with attraction.
Myke Towers is completely obsessed with a woman in this song, and he's not shy about it! The whole track is basically him admiring her, especially how she looks in a tiny skirt. He says, "Esa falda chiquitita qué bonita te queda" [That tiny skirt, how beautiful it looks on you]. He picks her up from university and makes it clear he thinks she's better than everyone else, who he says are just envious of her.
He describes her as a mix of different styles: "Mezcla lo sensual, la calle y la finura" [She mixes sensual, street, and class]. She's a focused student but also loves to party and wants a guy who will show her off. The lyrics get pretty direct about their physical relationship, even mentioning listening to Peso Pluma in the jacuzzi. It's a song about pure attraction and having fun, celebrating a woman who is confident, smart, and knows what she wants.