Jodió is a strong, informal verb that means 'screwed up' or 'messed up'. It's a very common slang term in many Spanish-speaking countries, often used to express that something went terribly wrong or was ruined.
In the song, Wisin sings, "Todo lo que era nuestro se jodió en solo un día" (Everything that was ours got screwed up in just one day). This word powerfully conveys the sudden and complete destruction of his relationship, making it a memorable and impactful choice for the lyrics.
Wisin spends this whole song trying to put a date on something: "¿Cuándo fue, cuándo fue que dejó de ser mía?" ("When was it, when was it that she stopped being mine?"). There is no villain in it. What he keeps turning up instead are small logistics — she used to call him to come get her, "Siempre me llamabas pa' buscarte" ("You always called me to come pick you up"), and the conversations ran past midnight, "Nos quedábamos hablando hasta tarde" ("We'd stay up talking late"). When he finally asks outright, it comes out as self-blame: "¿Qué hice mal, qué hice mal? Dímelo, vida mía" ("What did I do wrong, what did I do wrong? Tell me, my love").
He half-knows the answer — "Que tienes otro interés, ya sé que tú no me crees" ("That you've got another interest, I know you don't believe me") — and the rest of the song is about not letting it show. "Parezco tranquilo, pero por dentro sigo roto" ("I look calm, but inside I'm still broken") is the line everything else hangs on: the composure is for other people. On his own he is still handling the evidence, "¿Qué hago con las fotos, con los recuerdos de nosotros?" ("What do I do with the photos, with the memories of us?"), and still arguing the case to himself, "Tú todavía me quieres y yo no he dejado de amarte" ("You still love me and I haven't stopped loving you"). It ends where it began, on the same question nobody answers.