Despegamos means "we take off" or "we launch". While it literally refers to an airplane taking flight, it's used metaphorically here to signify a new beginning and leaving the past behind.
In the song, Antonio Orozco sings, "Hoy despegamos, lo de ayer no pesan nada" (Today we take off, yesterday's things weigh nothing). It's an inspiring and dynamic word that perfectly captures the song's theme of seizing the day and starting fresh with optimism.
“Hoy Será” (“Today It Will Be”) turns a moment of hesitation into a decision to act. Orozco opens by talking himself out of overthinking — “No estemos serios aquí no pasa nada” (Let's not be serious, nothing's happening here) — before the chorus commits: “Se trata de lo nuestro, se trata de empezar” (It's about us, it's about starting). The verses lean on physical images rather than vague optimism: “Tus manos son las venas, tus pies serán dos balas” (Your hands are the veins, your feet will be two bullets), “Hoy despegamos, lo de ayer no pesan nada” (Today we take off, yesterday's things weigh nothing). By the last chorus the doubt is behind him: “Las penas son de ayer” (Sorrows are from yesterday) — whatever held him back belongs to a day that's already over.